Skeletal rearrangement of arylmethylideneimidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7-diones in the synthesis of the corresponding imidazo[4,5-e]thiazolo[2,3-c]-1,2,4-triazine-2,8-diones

被引：15
|
作者：
Izmest'ev, Alexei N. [1 ]
Vasileva, Darya A. [1 ,2 ]
Melnikova, Elizaveta K. [3 ,4 ]
Kolotyrkina, Natalya G. [1 ]
Borisova, Irina A. [1 ]
Kravchenko, Angelina N. [1 ]
Gazieva, Galina A. [1 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia
[2] DI Mendeleev Univ Chem Technol Russia, Moscow 125047, Russia
[3] AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia
[4] Lomonosov Moscow State Univ, Moscow 119991, Russia
来源：
NEW JOURNAL OF CHEMISTRY | 2019年 / 43卷 / 02期
基金：
俄罗斯基础研究基金会;
关键词：
BIOLOGICAL-ACTIVITY; ANTICANCER ACTIVITY; DERIVATIVES; DESIGN; INHIBITORS; DISCOVERY;
D O I：
10.1039/c8nj05058a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Z)-1,3-Dialkyl-7-arylmethylidene-1,3a,4,9a-tetrahydroimidazo[4,5-e]thiazolo[2,3-c]-1,2,4-triazine-2,8(3H,7H)-diones have been prepared via a chemo- and diastereoselective aldol condensation of 1,3-dialkyl-3,3a,9,9a-tetrahydroimidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7(1H,6H)-diones with aromatic aldehydes followed by the skeletal rearrangement of thiazolotriazine fragments. We succeeded in synthesizing hitherto unknown products of alkali-induced skeletal rearrangement of 3a,9a-diphenyl substituted imidazothiazolotriazines.
引用
收藏
页码：1038 / 1052
页数：15
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