The present article analyzes the entropy generation on the nonlinear thermally radiating magnetohydrodynamic Casson nanofluid flow closer to the stagnation point inside a non-Darcy porous medium with viscous dissipation, magnetic dissipation, mixed convection, and heat generation. The induced magnetic field's impact and the implications of the chemical reaction and the activation energy are also included in the study. A mathematical model based on the substantive problem is developed, consisting of nonlinear partial differential equations and compatible boundary conditions. The mathematical model is converted to a set of nonlinear ordinary differential equations with appropriate boundary conditions using a suitable similarity transformation, which is then solved using the spectral quasi-linearization method. A complete examination is executed for achieving in-depth information of different varying flow parameters' consequences on the flow field and the significant physical quantities using several graphs and tables. Using the regression models on the reduced Nusselt number Nu(x)Re(x)(1/2) and the reduced Sherwood number Sh(x)Re(x)(1/2), the maximum relative errors are shown as 0.15%-0.30% and 0.016024%-0.016225%, respectively. The present results signify that the larger velocity ratio parameter boosts the velocity along the x-axis and the transverse velocity for M = 3, but the transverse velocity for M = 1, temperature, and induced magnetic field follow a reverse pattern.