A PDMS membrane based microbioreactor for perfused primary rat hepatocyte cultures.

被引：0

作者：

Ostrovidov, S ^{[1
]}

Jiang, J ^{[1
]}

Saka, Y ^{[1
]}

Fuji, T ^{[1
]}

机构：

[1] Univ Tokyo, LIMMS, CNRS, IIS,Meguro Ku, Tokyo 1538505, Japan

来源：

Micro Total Analysis Systems 2004, Vol 1 | 2005年 / 296期

关键词：

PDMS; hepatocytes; liver; microfluidic device; tissue engineering;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new technique to build PDMS membrane is presented. We used this membrane in a biological application and built some microbioreactors for cell cultures with inserted membrane. These microbioreactors were loaded with primary adult rat hepatocytes. Cultures monitoring showed a good rearrangement of the cells, a large increase in the albumin secretion and ammonium detoxification by the cells compared to static cultures and validated the use of these microbioreactors in cell cultures.

引用

页码：477 / 479

页数：3

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