Knockdown of phospholamban using antisense oligonucleotides halts disease progression and resolves protein aggregation in mice with advanced phospholamban p.Arg14del cardiomyopathy

被引：0

作者：

Eijgenraam, T. R. ^{[1
]}

Stege, N. M. ^{[1
]}

Teixeira, V. Oliveira Nunes ^{[1
]}

Beverborg, N. Grote ^{[1
]}

Spaeter, D. ^{[2
]}

Knoell, R. ^{[2
]}

Hansson, K. M. ^{[2
]}

Amilon, C. ^{[2
]}

Janzen, D. ^{[2
]}

Yeh, S. T. ^{[3
]}

Mullick, A. E. ^{[3
]}

Van der Meer, P.

De Boer, R. A.

Sillje, H. H. W.

机构：

[1] Univ Med Ctr Groningen, Cardiol, Groningen, Netherlands

[2] AstraZeneca, Gothenburg, Sweden

[3] Ionis Pharmaceut, Carlsbad, CA USA

来源：

EUROPEAN JOURNAL OF HEART FAILURE | 2022年 / 24卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：277 / 277

页数：1

共 25 条

[1] The Phospholamban p.Arg14del Mutation-Related Cardiomyopathy Is an Arrhythmogenic Cardiomyopathy and Protein Aggregation Disease
te Rijdt, W. P.
van der Zwaag, P.
van den Berg, M. P.
van Tintelen, P.
Suurmeijer, A. J.
LABORATORY INVESTIGATION, 2014, 94 : 94A - 94A
[2] Phospholamban p.Arg14del cardiomyopathy is characterized by phospholamban aggregates which are degraded by autophagy
te Rijdt, W. P.
Tintelen, J. P.
Vink, A.
van der Wal, A. C.
de Boer, R. A.
van den Berg, M. P.
Suurmeijer, A. J. H.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2016, 46 : 17 - 17
[3] Phospholamban p.Arg14del cardiomyopathy is characterized by phospholamban aggregates, aggresomes, and autophagic degradation
te Rijdt, Wouter P.
van Tintelen, J. Peter
Vink, Aryan
van der Wal, Allard C.
de Boer, Rudolf A.
van den Berg, Maarten P.
Suurmeijer, Albert J. H.
HISTOPATHOLOGY, 2016, 69 (04) : 542 - 550
[4] Phospholamban p.Arg14del Cardiomyopathy: A Japanese Case Series
Tabata, Tomoka
Kuramoto, Yuki
Ohtani, Tomohito
Miyawaki, Hiroshi
Miyashita, Yohei
Sera, Fusako
Kioka, Hidetaka
Higo, Shuichiro
Asano, Yoshihiro
Hikoso, Shungo
Sakata, Yasushi
INTERNAL MEDICINE, 2022, 61 (13) : 1987 - 1993
[5] Phospholamban immunostaining is a highly sensitive and specific method for diagnosing phospholamban p.Arg14del cardiomyopathy
te Rijdt, W. P.
van der Klooster, J.
Vink, A.
Suurmeijer, A.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2017, 47 : 32 - 33
[6] Phospholamban Immunostaining is a Highly Sensitive and Specific Method for Diagnosing Phospholamban p.Arg14del Cardiomyopathy
Rijdt, W. P. te
van der Klooster, Z. J.
van Tintelen, J. P.
Dooijes, D.
Asselbergs, F. W.
van den Berg, M. P.
Vink, A.
Suurmeijer, A. J. H.
CIRCULATION, 2016, 134
[7] Antisense Therapy Attenuates Phospholamban p.(Arg14del) Cardiomyopathy in Mice and Reverses Protein Aggregation
Eijgenraam, Tim R.
Stege, Nienke M.
Oliveira Nunes Teixeira, Vivian
de Brouwer, Remco
Schouten, Elisabeth M.
Grote Beverborg, Niels
Sun, Liu
Spater, Daniela
Knoll, Ralph
Hansson, Kenny M.
Amilon, Carl
Janzen, David
Yeh, Steve T.
Mullick, Adam E.
van der Meer, Peter
de Boer, Rudolf A.
Sillje, Herman H. W.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (05)
[8] Phospholamban immunostaining is a highly sensitive and specific method for diagnosing phospholamban p.Arg14del cardiomyopathy
te Rijdt, Wouter P.
van der Klooster, Z. Joy
Hoorntje, Edgar T.
Jongbloed, Jan D. H.
van der Zwaag, Paul A.
Asselbergs, Folkert W.
Dooijes, Dennis
de Boer, Rudolf A.
van Tintelen, J. Peter
van den Berg, Maarten P.
Vink, Aryan
Suurmeijer, Albert J. H.
CARDIOVASCULAR PATHOLOGY, 2017, 30 : 23 - 26
[9] Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy
te Rijdt, Wouter P.
Asimaki, Angeliki
Jongbloed, Jan D. H.
Hoorntje, Edgar T.
Lazzarini, Elisabetta
van der Zwaag, Paul A.
de Boer, Rudolf A.
van Tintelen, J. Peter
Saffitz, Jeffrey E.
van den Berg, Maarten P.
Suurmeijer, Albert J. H.
CARDIOVASCULAR PATHOLOGY, 2019, 40 : 2 - 6
[10] The phospholamban p.Arg14del founder mutation in Dutch patients with arrhythmogenic cardiomyopathy
van der Heijden, J. F.
Hassink, R. J.
NETHERLANDS HEART JOURNAL, 2013, 21 (06) : 284 - 285

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