Syndecan-4 Enhances Therapeutic Angiogenesis after Hind Limb Ischemia in Mice with Type 2 Diabetes

被引：26
|
作者：
Das, Subhamoy [1 ]
Monteforte, Anthony J. [1 ]
Singh, Gunjan [1 ]
Majid, Marjan [1 ]
Sherman, Michael B. [2 ]
Dunn, Andrew K. [1 ]
Baker, Aaron B. [1 ,3 ,4 ,5 ]
机构：
[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX USA
[2] Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA
[3] Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA
[4] Univ Texas Austin, Inst Computat Engn & Sci, Austin, TX 78712 USA
[5] Univ Texas Austin, Inst Biomat Drug Delivery & Regenerat Med, Austin, TX 78712 USA
来源：
ADVANCED HEALTHCARE MATERIALS | 2016年 / 5卷 / 09期
关键词：
PERIPHERAL ARTERIAL-DISEASE; FIBROBLAST GROWTH FACTOR-2; INTERMITTENT CLAUDICATION; DOUBLE-BLIND; TRIAL; PLACEBO;
D O I：
10.1002/adhm.201500993
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Delivering syndecan-4 with FGF-2 improves the effectiveness of FGF-2 therapy for ischemia in the diabetic disease state. The syndecan-4 proteoliposomes significantly enhance in vitro tubule formation as well as blood perfusion and vessel density in the ischemic hind limbs of diseased ob/ob mice. Syndecan-4 therapy also induces a marked immunomodulation in the tissues, increasing the polarization of macrophages toward the M2 phenotype. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：1008 / 1013
页数：6
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