Repression of telomere-associated genes by microglia activation in neuropsychiatric disease

被引：16

作者：

Kronenberg, Golo ^{[1
,2
,3
,4
]}

Uhlemann, Ria ^{[2
,3
]}

Schoener, Johanna ^{[1
,2
,3
]}

Wegner, Stephanie ^{[2
,3
]}

Boujon, Valerie ^{[2
,3
]}

Deigendesch, Nikolas ^{[5
]}

Endres, Matthias ^{[2
,3
,6
,7
,8
]}

Gertz, Karen ^{[2
,3
]}

机构：

[1] Charite Campus Mitte, Klin Psychiat & Psychotherapie, Berlin, Germany

[2] Charite, Ctr Stroke Res Berlin CSB, Berlin, Germany

[3] Charite, Klin & Hochschulambulanz Neurol, Berlin, Germany

[4] Univ Med Rostock, Klin & Poliklin Psychiat & Psychotherapie, Gehlsheimer Str 20, D-18147 Rostock, Germany

[5] Charite, Inst Neuropathol, Berlin, Germany

[6] German Ctr Neurodegenerat Dis DZNE, Charitepl 1, D-10117 Berlin, Germany

[7] Charite, Cluster Excellence NeuroCure, Berlin, Germany

[8] DZHK German Ctr Cardiovasc Res, Partner Site Berlin,Charitepl 1, D-10117 Berlin, Germany

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2017年 / 267卷 / 05期

关键词：

Alzheimer's disease; Microglia; Mitochondrial biogenesis; Neurodegenerative disease; Telomerase; ENDOTHELIAL FUNCTION; MICE; STROKE; CELLS;

D O I：

10.1007/s00406-016-0750-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Microglia senescence may promote neuropsychiatric disease. This prompted us to examine the relationship between microglia activation states and telomere biology. A panel of candidate genes associated with telomere maintenance, mitochondrial biogenesis, and cell-cycle regulation were investigated in M1- and M2-polarized microglia in vitro as well as in MACS-purified CD11b+ microglia/brain macrophages from models of stroke, Alzheimer's disease, and chronic stress. M1 polarization, ischemia, and Alzheimer pathology elicited a strikingly similar transcriptomic profile with, in particular, reduced expression of murine Tert. Our results link classical microglia activation with repression of telomere-associated genes, suggesting a new mechanism underlying microglia dysfunction.

引用

页码：473 / 477

页数：5

共 50 条

[41] Telomere-associated polymorphisms correlate with cardiovascular disease mortality in Caucasian women: The Cardiovascular Health Study
Burnett-Hartman, Andrea N.
Fitzpatrick, Annette L.
Kronmal, Richard A.
Psaty, Bruce M.
Jenny, Nancy S.
Bis, Josh C.
Tracy, Russ P.
Kimura, Masayuki
Aviv, Abraham
MECHANISMS OF AGEING AND DEVELOPMENT, 2012, 133 (05) : 275 - 281
[42] TELOMERE-ASSOCIATED CHROMOSOME FRAGMENTATION - APPLICATIONS IN GENOME MANIPULATION AND ANALYSIS
FARR, CJ
STEVANOVIC, M
THOMSON, EJ
GOODFELLOW, PN
COOKE, HJ
NATURE GENETICS, 1992, 2 (04) : 275 - 282
[43] hSnm1B is a novel telomere-associated protein
Freibaum, Brian D.
Counter, Christopher M.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (22) : 15033 - 15036
[44] Genetic mapping of telomere-associated sequences in soybean (Glycine max)
刘峰
张德水
张劲松
陈受宜
ProgressinNaturalScience, 2001, (05) : 33 - 39
[45] Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution
Lewis, Karen A.
Wuttke, Deborah S.
STRUCTURE, 2012, 20 (01) : 28 - 39
[46] Short Telomeres and Autoantibodies Targeting Telomere-Associated Proteins in Scleroderma
Adler, Britany
Shah, Ami
Boin, Francesco
Wolters, Paul
Casciola-Rosen, Livia
Rosen, Antony
ARTHRITIS & RHEUMATOLOGY, 2020, 72
[47] EVOLUTIONARY RELATIONS BETWEEN SUBTYPES OF TELOMERE-ASSOCIATED REPEATS IN CHIRONOMUS
COHN, M
EDSTROM, JE
JOURNAL OF MOLECULAR EVOLUTION, 1991, 32 (06) : 463 - 468
[48] AN ANALYSIS OF XQ BREAKPOINTS CREATED BY TELOMERE-ASSOCIATED CHROMOSOME FRAGMENTATION
BAYNE, R
TAGGART, MT
FARR, C
PETIT, C
GUILFORD, P
TONIOLO, D
SALA, C
COOKE, HJ
CYTOGENETICS AND CELL GENETICS, 1993, 64 (3-4): : 175 - 175
[49] The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinicopathological parameters and clinical outcome
Salhob, M.
Jiang, W. G.
Newhold, R. F.
Mokhel, K.
BREAST CANCER RESEARCH AND TREATMENT, 2007, 106 : S283 - S283
[50] Cloning and preliminary verification of telomere-associated sequences in upland cotton
Liu, Yuling
Liu, Zhen
Wei, Yangyang
Wang, Yanjun
Shuang, Jiaran
Peng, Renhai
COMPARATIVE CYTOGENETICS, 2020, 14 (02) : 183 - 195

← 1 2 3 4 5 →