Eccrine Squamous Syringometaplasia Associated With Lichen Sclerosus et Atrophicus

被引：0
|
作者：
Mishlab, Salih [1 ,2 ]
Cohen, Itzhak [2 ,3 ]
Bergman, Reuven [1 ,2 ,4 ]
机构：
[1] Rambam Hlth Care Campus, Dept Dermatol, Haifa, Israel
[2] Ruth & Bruce Rappaport Fac Med, Haifa, Israel
[3] Western Galilee Med Ctr, Dept Pathol, Nahariyya, Israel
[4] Rambam Hlth Care Campus, Dept Pathol, Haifa, Israel
来源：
AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2022年 / 44卷 / 08期
关键词：
eccrine squamous syringometaplasia; LSA; DISTINCTIVE ERUPTION; CARCINOMA; PATIENT;
D O I：
10.1097/DAD.0000000000002226
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Eccrine squamous syringometaplasia (ESS) has been associated with several conditions including morphea, linear scleroderma, and burns. It is yet to be reported in lichen sclerosus et atrophicus (LSA). We describe a bullous LSA plaque on the forearm of a woman with pre-existing genital LSA and vitiligo. Besides the histopathological findings of bullous LSA, numerous small irregular squamoid structures were present in the mid and upper dermis always above the normal eccrine glands. The histopathology, periodic acid-Schiff stain, and positive immunostains for P63, low molecular weight keratins 8&18, epithelial membrane antigen, and carcinoembryonic antigen supported the diagnosis of ESS. The pathogenesis of ESS in LSA may be related to ischemia, inflammation, and fibrosis.
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页码：590 / 593
页数：4
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