Preparation and study on the solid inclusion complex of cloxacillin sodium with β-cyclodextrin

被引：8
|
作者：
Chao, Jian-Bin [1 ]
Zhang, Bing-Tai
机构：
[1] Shanxi Univ, Inst Modern Chem, Taiyuan 030006, Peoples R China
[2] Shanxi Med Univ, Clin Hosp 2, Taiyuan 030006, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2007年 / 68卷 / 01期
关键词：
cloxacillin sodium; beta-CD; inclusion complex; 1D NMR; 2D NMR;
D O I：
10.1016/j.saa.2006.10.058
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
The interaction of cloxacillin sodium with beta-cyclodextrin (beta-CD) has been studied by several analytical techniques, including H-1 NMR, fluorescence spectroscopy, infrared spectroscopy. In this paper, solid inclusion complex of cloxacillin sodium with beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, infrared spectroscopy and 1D, 2D NMR. The experimental results confirmed the existence of 1: 1 inclusion complex of cloxacillin sodium with beta-CD. The formation constant of complex was determined by fluorescence method and H-1 NMR. Spacial configuration of complex has been proposed on 2D NMR technique. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：108 / 112
页数：5
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