Nitric oxide release from a photoactive water-soluble ruthenium nitrosyl. Biologicaleffects

被引：16

作者：

Crisalli, Meredith A. ^{[1
]}

Franco, Lilian P. ^{[2
]}

Silva, Bruno R. ^{[2
]}

Holanda, Alda K. M. ^{[1
,3
]}

Bendhack, Lusiane M. ^{[2
]}

Da Silva, Roberto S. ^{[2
]}

Ford, Peter C. ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, Brazil

[3] Univ Fed Ceara Cx, Dept Quim Organ & Inorgan, Fortaleza, Ceara, Brazil

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2018年 / 71卷 / 11-13期

基金：

巴西圣保罗研究基金会; 美国国家科学基金会;

关键词：

Ruthenium nitrosyl; photochemical release; nitric oxide; myography; cell viability; SALEN-NITROSYL; CHEMICAL BIOLOGY; NO; COMPLEXES; DELIVERY; PHOTOCHEMISTRY; PHOTOREACTIVITY; PHOTOLYSIS; PATHWAYS; AGENT;

D O I：

10.1080/00958972.2018.1469129

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This research presents the synthesis and characterization of the photochemical nitric oxide (NO) precursor Ru(salenCO(2)H)(NO)Cl (1, salenCO(2)H=N,N'-ethylenebis(3,3'-bis-carboxylsalicylideneiminato). This water-soluble ruthenium nitrosyl releases NO upon photolysis with a quantum yield that is pH dependent owing to the nitrosyl to nitrite conversion of that axial ligand at higher pH. Also described are the water, oxygen, and thermal stability of 1 and the cytotoxicity and the vascular relaxivity properties of 1 in the dark and under photolysis. [GRAPHICS] .

引用

页码：1690 / 1703

页数：14

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