Nitric oxide release from a photoactive water-soluble ruthenium nitrosyl. Biologicaleffects

被引：16
|
作者：
Crisalli, Meredith A. [1 ]
Franco, Lilian P. [2 ]
Silva, Bruno R. [2 ]
Holanda, Alda K. M. [1 ,3 ]
Bendhack, Lusiane M. [2 ]
Da Silva, Roberto S. [2 ]
Ford, Peter C. [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, Brazil
[3] Univ Fed Ceara Cx, Dept Quim Organ & Inorgan, Fortaleza, Ceara, Brazil
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2018年 / 71卷 / 11-13期
基金：
巴西圣保罗研究基金会; 美国国家科学基金会;
关键词：
Ruthenium nitrosyl; photochemical release; nitric oxide; myography; cell viability; SALEN-NITROSYL; CHEMICAL BIOLOGY; NO; COMPLEXES; DELIVERY; PHOTOCHEMISTRY; PHOTOREACTIVITY; PHOTOLYSIS; PATHWAYS; AGENT;
D O I：
10.1080/00958972.2018.1469129
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
This research presents the synthesis and characterization of the photochemical nitric oxide (NO) precursor Ru(salenCO(2)H)(NO)Cl (1, salenCO(2)H=N,N'-ethylenebis(3,3'-bis-carboxylsalicylideneiminato). This water-soluble ruthenium nitrosyl releases NO upon photolysis with a quantum yield that is pH dependent owing to the nitrosyl to nitrite conversion of that axial ligand at higher pH. Also described are the water, oxygen, and thermal stability of 1 and the cytotoxicity and the vascular relaxivity properties of 1 in the dark and under photolysis. [GRAPHICS] .
引用
收藏
页码：1690 / 1703
页数：14
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