The relationship between IL-1 gene polymorphism and marginal bone loss around dental implants

Purpose: Early marginal bone loss around dental implants has been found during the bone healing period before stage II surgery despite a lack of apparent cause, and the etiology of this bone loss is unclear. This study was designed to investigate whether interleukin-I gene polymorphism is associated with the marginal bone loss around the implants before stage II. Materials and Methods: One hundred forty-three implants were placed in 59 patients. The patients were divided into 2 groups: 1) test group: with I or more marginal bone loss greater than 0.5 mm; and 2) control group: with marginal bone resorption less than 0.5 turn. Polymorphisms of the IL-1 alpha and IL-1 beta genes (IL-1A-889, IL-1B-511, and IL-1B+3954) were detected by restriction fragment length polymorphism using Ncol, AvaI, and TaqI digestion after polymerase chain reactions. Results: The frequency of IL-1B-511 II/II was significantly higher among patients in early marginal bone loss (+) group than those in early marginal bone loss (-) group (P < .05). Multiple logistic regressions showed the OR of the II/II versus the I/I+I/II of the IL-1B-511 genotype was 3.933 between the 2 groups. The difference was statistically significant (P < .05). There was no significant difference between the other risk factors. Conclusion: These results suggest that the IL-1B-511 II/II genotype in individuals is associated with early marginal bone loss around implants. (c) 2007 American Association of Oral and Maxillofacial Surgeons.