A convenient approach to the synthesis of dialkyl 5-oxo-1,2-dihydro-5H-chromeno[4,3-b]pyridine-2,3-dicarboxylates

被引：4
|
作者：
Glasnov, Toma N. [1 ]
Ivanov, Ivo C. [1 ]
机构：
[1] Med Univ Sofia, Fac Pharm, Dept Organ Chem, BG-1000 Sofia, Bulgaria
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 10期
关键词：
annelated ring system; coumarin; enaminoaldehydes; Wittig reaction;
D O I：
10.1080/00397910801929465
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Coumarin and its analogs are considered privileged scaffolds in the current synthetic and pharmacological research. The chemical behavior of enaminocarbaldehydes of the coumarin moiety under intramolecular Wittig reaction conditions in the presence of triphenylphosphine and dimethyl or diethyl acetylenedicarboxylates has been studied, resulting in the isolation of a series of dimethyl and diethyl 5-oxo-1,2-dihydro-5H-chromeno[4,3-b]pyridine-2,3-dicarboxylates in good to high yields.
引用
收藏
页码：1579 / 1588
页数：10
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