The intestinal epithelial response to damage

被引：18

作者：

Weichselbaum, Laura ^{[1
,2
,3
,4
]}

Klein, Ophir D. ^{[1
,2
,5
,6
]}

机构：

[1] Univ Calif San Francisco, Program Craniofacial Biol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Orofacial Sci, San Francisco, CA 94143 USA

[3] Univ Libre Bruxelles, Inst Med Immunol, B-6041 Gosselies, Belgium

[4] Univ Libre Bruxelles, Lab Expt Gastroenterol, B-1070 Brussels, Belgium

[5] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

来源：

SCIENCE CHINA-LIFE SCIENCES | 2018年 / 61卷 / 10期

关键词：

intestine; regeneration; microenvironment; STEM-CELL NICHE; INNATE LYMPHOID-CELLS; SECRETORY PRECURSORS; COLONIC EPITHELIUM; TISSUE-DAMAGE; REGENERATION; HOMEOSTASIS; LGR5; ACTIVATION; EXPRESSION;

D O I：

10.1007/s11427-018-9331-y

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The constant renewal of the intestinal epithelium is fueled by intestinal stem cells (ISCs) lying at the base of crypts, and these ISCs continuously give rise to transit-amplifying progenitor cells during homeostasis. Upon injury and loss of ISCs, the epithelium has the ability to regenerate by the dedifferentiation of progenitor cells that then regain stemness and repopulate the pool of ISCs. Epithelial cells receive cues from immune cells, mesenchymal cells and the microbiome to maintain homeostasis. This review focuses on the response of the epithelium to damage and the interplay between the different intestinal compartments.

引用

页码：1205 / 1211

页数：7

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