Total synthesis of atorvastatin via a late-stage, regioselective 1,3-dipolar munchnone cycloaddition

被引：20
|
作者：
Lopchuk, Justin M. [1 ]
Gribble, Gordon W. [1 ]
机构：
[1] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 23期
关键词：
Munchnone; 1,3-Dipolar cycloaddition; Atorvastatin; Pyrrole; Mesoionic; HMG-COA REDUCTASE; MULTICOMPONENT SYNTHESIS; CARBON-MONOXIDE; IMIDAZOLINES; DERIVATIVES; INHIBITORS; PYRROLES; IMINES;
D O I：
10.1016/j.tetlet.2014.12.104
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Atorvastatin was prepared in seven steps from commercially available 4-fluorophenylacetic acid. The key 1,3-dipolar cycloaddition was conducted regioselectively using a complex munchnone which was prepared in five steps on decagram scale. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3208 / 3211
页数：4
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