Aromatase inhibitors and male breast cancer

被引：30
|
作者：
Arriola, E. [1 ,2 ]
Hui, E. [2 ]
Dowsett, M. [1 ]
Smith, I. E. [2 ]
机构：
[1] Royal Marsden Hosp, Dept Biochem, London SW3 6JJ, England
[2] Royal Marsden Hosp, Breast Unit, London SW3 6JJ, England
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2007年 / 9卷 / 03期
关键词：
male; breast neoplasm; aromatase inhibitor; letrozole; oestradiol;
D O I：
10.1007/s12094-007-0034-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The majority of breast cancers in male patients are hormone receptor positive. Tamoxifen has proven to be successful in both adjuvant and metastatic settings and remains the standard of care. Given the improved outcomes in female patients with aromatase inhibitors (AI), these drugs have become a potential therapeutic tool for male patients. Preliminary data show effective suppression of oestradiol levels in males treated with AI and some reports have demonstrated objective responses. Here we report a case of a male patient with metastatic breast cancer treated with letrozole who achieved clinical response associated with a decrease in blood oestradiol levels.
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页码：192 / 194
页数：3
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