Phagocytosis: what's on the menu?

被引：32
|
作者：
Lancaster, Charlene E. [1 ,2 ]
Ho, Cheuk Y. [1 ]
Hipolito, Victoria E. B. [3 ,4 ]
Botelho, Roberto J. [3 ,4 ]
Terebiznik, Mauricio R. [1 ,2 ]
机构：
[1] Univ Toronto Scarborough, Dept Biol Sci, Toronto, ON M1C 1A4, Canada
[2] Univ Toronto Scarborough, Dept Cell & Syst Biol, Toronto, ON M1C 1A4, Canada
[3] Ryerson Univ, Mol Sci Grad Program, Toronto, ON M5S 2S1, Canada
[4] Ryerson Univ, Dept Chem & Biol, Toronto, ON M5B 2K3, Canada
来源：
BIOCHEMISTRY AND CELL BIOLOGY | 2019年 / 97卷 / 01期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
phagocytosis; target morphology; phagocytic plasticity; phagosomal maturation; phagocytic cup; NEUTROPHIL EXTRACELLULAR TRAPS; NONPROFESSIONAL PHAGOCYTES; STAPHYLOCOCCUS-AUREUS; ANTIGEN PRESENTATION; PROTOZOAN PREDATION; BACTERIAL SURVIVAL; EPIDERMAL-CELLS; ACTIN; PHAGOSOME; ENDOSOME;
D O I：
10.1139/bcb-2018-0008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Phagocytosis is an evolutionarily conserved process. In Protozoa, phagocytosis fulfills a feeding mechanism, while in Metazoa, phagocytosis diversified to play multiple organismal roles, including immune defence, tissue homeostasis, and remodeling. Accordingly, phagocytes display a high level of plasticity in their capacity to recognize, engulf, and process targets that differ in composition and morphology. Here, we review how phagocytosis adapts to its multiple roles and discuss in particular the effect of target morphology in phagocytic uptake and phagosome maturation.
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页码：21 / 29
页数：9
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