Studies on the synthesis, crystal structure and antitumor activities of Mn(II) complex derived from the desulfurization of N-(p-nitrophenyl)-N′-(methoxycarbonyl)thiourea and o-phenanthroline

被引：4

作者：

Shen, X ^{[1
]}

Shan, J

Sun, HB

Kang, BS

机构：

[1] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China

[2] Zhongshan Univ, Dept Chem, Guangzhou 510275, Peoples R China

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 1999年 / 46卷 / 02期

关键词：

synthesis; crystal structure; antitumor activity; manganese(II) complex; thiourea compound;

D O I：

10.1002/jccs.199900027

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One new Mn(II) complex, 1, MnL2(phen)(2) (L = p-nitrsphenylcyanamido-N, phen = o-phenanthroline) has been synthesized and crystallographically characterized, Complex 1 was obtained from the desulfurization and hydrolysis of H(2)pmt (H(2)pmt = N-(p-nitrophenyl)-N'-(methoxycarbonyl)thiourea) in alkaline media. 1 crystallized in the triclinic space group P-l with a = 11.0320(3), b = 11.7831(4), c = 12.9288(4) Angstrom; alpha = 87.3590(10), beta = 81.7500(10), gamma= 84.0080(10)degrees. Preliminary pharmacological tests showed that complex 1 exhibited definite inhibition activities against human ovary tumor 3A0 and mice P388 in vitro.

引用

页码：179 / 183

页数：5

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