Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279

被引：21
|
作者：
Yu, Guihong [1 ]
Wang, Shuai [2 ,3 ]
Wang, Lu [1 ]
Che, Qian [1 ]
Zhu, Tianjiao [1 ]
Zhang, Guojian [1 ,4 ]
Gu, Qianqun [1 ]
Guo, Peng [2 ,3 ]
Li, Dehai [1 ,4 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
[2] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China
[3] Peking Union Med Coll, Beijing 100193, Peoples R China
[4] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
来源：
MARINE DRUGS | 2018年 / 16卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Penicillium steckii; tanzawaic acid derivatives; lipid-lowering activity; MARINE-DERIVED FUNGUS; METABOLIC SYNDROME; TANZAWAIC ACIDS; AGENTS; ALKALOIDS; CITRINUM;
D O I：
10.3390/md16010025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Seven new polyketides, named tanzawaic acids R-X (1-6, 11), along with seven known analogues (7-10 and 12-14), were isolated from Penicillium steckii HDN13-279. Their structures, including the absolute configurations, were elucidated by NMR, MS, X-ray diffraction, circular dichroism (CD) analyses and chemical derivatization. Five compounds (2, 3, 6, 10 and 12) significantly decreased the oleic acid (OA)-elicited lipid accumulation in HepG2 liver cells at the concentration of 10 M, among which, four compounds (3, 6, 10 and 12) significantly decreased intracellular total cholesterol (TC) levels and three Compounds (3, 6, and 10) significantly decreased intracellular triglyceride (TG) levels. Moreover, the TG-lowering capacities of compounds 6 and 10 were comparable with those of simvastatin, with the TG levels being nearly equal to blank control. This is the first report on the lipid-lowering activity of tanzawaic acid derivatives.
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页数：13
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