A thiourea-based fluorescent chemosensor for bioimaging hypochlorite

被引：21

作者：

So, Haeri ^{[1
]}

Lee, Hangyul ^{[1
]}

Lee, Gyu Dong ^{[2
]}

Kim, Mingeun ^{[3
]}

Lim, Mi Hee ^{[3
]}

Kim, Ki-Tae ^{[2
]}

Kim, Cheal ^{[1
]}

机构：

[1] Seoul Natl Univ Sci & Technol SNUT, Dept Fine Chem, Seoul 01178, South Korea

[2] Seoul Natl Univ Sci & Technol SNUT, Dept Environm Engn, Seoul 01178, South Korea

[3] Korea Adv Inst Sci & Technol KAIST, Dept Chem, Daejeon 33141, South Korea

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2020年 / 89卷 / 89期

基金：

新加坡国家研究基金会;

关键词：

Thiourea; Hypochlorite; Fluorescence Chemosensor; Cells; Zebrafish; LIVING CELLS; SCHIFF-BASE; PROBE; ACID; THIOSEMICARBAZIDE; COMPLEX; ZN2+;

D O I：

10.1016/j.jiec.2020.06.016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A thiourea-based fluorescent turn-off chemosensor FHC was developed for recognizing hypochlorite. With the addition of hypochlorite to FHC, FHC displayed a specific desulfurization reaction of the thiourea group followed by the fluorescent quenching response. The fluorescent turn-off response of FHC to hypochlorite was very fast to finish within a few seconds. Detection limit of hypochlorite was determined to be 0.43 mu.M.FHC can be applied for the bioimaging of hypochlorite in both HeLa cells and zebrafish. Response process of FHC to hypochlorite, via the desulfurization of the thiourea moiety, was demonstrated, based on H-1 NMR titrations, ESI-mass, fluorescent and UV-vis titrations and DFT calculations. (C) 2020 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：436 / 441

页数：6

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