Hsa circ 0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis

Osteosarcoma (OS) is a primary malignant bone tumor with a high fatality rate. Circular RNAs (circRNAs) are a type of endogenous noncoding RNA that have been verified to participate in cancer pathophysiological processes. We aim to investigate the roles of circRNAs in osteosarcoma tumorigenesis. In the present study, we showed that hsa circ 0003732 was up-regulated in OS tissues and elevated level of hsa circ 0003732 was linked to poor prognosis of OS patients. Functional investigation indicated that hsa circ 0003732 promoted proliferation of OS cells. Furthermore, we identified miR-545 as the hsa circ 0003732-associated microRNA and CCNA2 was a direct target of miR-545. In addition, hsa circ 0003732 could elevate CCNA2 expression via miR-545, resulting in the promotion of OS cells proliferation. Altogether, our findings demonstrate that hsa circ 0003732 promotes OS cells proliferation via miR-545/CCNA2 axis and imply hsa circ 0003732 may be a potential prognosis biomarker and therapeutic target for OS.