Regulation of Proteolysis in the Gram-Negative Bacterial Envelope

被引：7
|
作者：
Raivio, Tracy L. [1 ]
机构：
[1] Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada
来源：
JOURNAL OF BACTERIOLOGY | 2018年 / 200卷 / 03期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
DegP; Escherichia coli; Gram negative; YjfN; bacterial envelope; proteolysis; stress response; STRESS-RESPONSE; QUALITY-CONTROL; MEMBRANE PROTEINS; PLASMA-MEMBRANE; SUBSTRATE; DEGRADATION; PROTEASES; COMPLEX; DEGP; ACTIVATION;
D O I：
10.1128/JB.00639-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Proteolysis is carefully regulated to prevent the untimely destruction of critical proteins. In this issue of the Journal of Bacteriology, Kim and colleagues identify YjfN as a proteolytic regulator that stimulates the activity of the DegP/HtrA protease of Escherichia coli (S. Kim, I. Song, G. Eom, and S. Kim, J Bacteriol 200:e00519-17, 2018, https://doi.org/10.1128/JB.00519-17). The suicide destruction and transcriptional regulation of YjfN limit its activity to conditions in which there are likely to be many misfolded substrate proteins present.
引用
收藏
页数：6
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