Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men

被引：9

作者：

Kawamoto, Teruyoshi ^{[1
]}

Kokaze, Akatsuki ^{[1
,2
]}

Ishikawa, Mamoru ^{[2
,3
]}

Matsunaga, Naomi ^{[2
]}

Karita, Kanae ^{[2
]}

Yoshida, Masao ^{[2
]}

Shimada, Naoki ^{[1
]}

Ohtsu, Tadahiro ^{[1
]}

Shirasawa, Takako ^{[1
]}

Ochiai, Hirotaka ^{[1
]}

Ito, Taku ^{[1
]}

Hoshino, Hiromi ^{[1
]}

Takashima, Yutaka ^{[2
]}

机构：

[1] Showa Univ, Sch Med, Dept Publ Hlth, Shinagawa Ku, Tokyo 1428555, Japan

[2] Kyorin Univ, Sch Med, Dept Publ Hlth, Mitaka, Tokyo 1818611, Japan

[3] Mito Red Cross Hosp, Mito, Ibaraki 3100011, Japan

来源：

LIPIDS IN HEALTH AND DISEASE | 2011年 / 10卷

关键词：

DENSITY-LIPOPROTEIN CHOLESTEROL; MYOCARDIAL-INFARCTION; COFFEE CONSUMPTION; A/C POLYMORPHISM; DRINKING; POPULATION; HYPERTENSION; METAANALYSIS; GENOTYPE; PLASMA;

D O I：

10.1186/1476-511X-10-105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Combined effects between mitochondrial DNA 5178 (Mt5178) C/A polymorphism and alcohol consumption on the risk of hypertension or hyperuricemia have been reported. The objective of this study was to investigate whether Mt5178 C/A polymorphism modulates the effects of alcohol consumption on the risk of dyslipidemia. Methods: A total of 394 male subjects were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the combined effect of Mt5178 polymorphism and alcohol consumption on the risk of dyslipidemia was conducted. Results: For men with Mt5178C, alcohol consumption was significantly and negatively associated with the risk of hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol >= 140 mg/dl) (P for trend = 0.015). After adjustment for age, body mass index (BMI), habitual smoking, coffee consumption and use of antihypertensive medicine, the odds ratio (OR) for hyper-LDL cholesterolemia was significantly lower in daily drinkers with Mt5178C than non-drinkers with Mt5178C (OR = 0.360, 95% confidence intervals: 0.153-0.847). A significant and negative association between alcohol consumption and serum LDL cholesterol levels was also observed in Mt5178C genotypic men (P for trend < 0.01). On the other hand, the association between Mt5178A genotype and risk of hyper-LDL cholesterolemia does not appear to depend on alcohol consumption. Conclusions: For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia.

引用

页数：6

共 41 条

[41] Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan public health center-based prospective study
Otani, T
Iwasaki, M
Yamamoto, S
Sobue, T
Hanaoka, T
Inoue, M
Tsugane, S
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2003, 12 (12) : 1492 - 1500

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