Immobilization stress-induced thymocyte apoptosis in rats

被引：12

作者：

Hatanaka, K ^{[1
]}

Ikegaya, H ^{[1
]}

Takase, I ^{[1
]}

Kobayashi, M ^{[1
]}

Iwase, H ^{[1
]}

Yoshida, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Forens Med, Bunkyo Ku, Tokyo 1130033, Japan

来源：

LIFE SCIENCES | 2001年 / 69卷 / 02期

关键词：

immobilization stress; thymocyte; apoptosis; glucocorticoid;

D O I：

10.1016/S0024-3205(01)01106-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Immobilization of rats is a well known model of emotional stress. We studied apoptosis in rat thymocytes during immobilization for 2-8 hours (h). Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL)-positive cells increased with time of immobilization. The positive cells increased significantly after 2 h and comprised about 33% of total cells after 8 h. The apoptotic cells aggregated as scattered foci predominantly in the cortex of the thymus and diffusely distributed with time of the stress. The DNA laddering also increased with time of immobilization, which was inhibited by a glucocorticoid receptor antagonist, RU-486. These results suggest that the emotional stress evoked by immobilization induces thymocyte apoptosis through glucocorticoid overflow. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：155 / 165

页数：11

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