Palladium(II)-Catalyzed Regioselective syn-Hydroarylation of Disubstituted Alkynes Using a Removable Directing Group

被引：91
|
作者：
Liu, Zhen [1 ]
Derosa, Joseph [1 ]
Engle, Keary M. [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 39期
关键词：
PALLADIUM-CATALYZED HYDROARYLATION; RH/M-TPPTC CATALYST; ARYLBORONIC ACIDS; ORGANOBORONIC ACIDS; BORONIC ACIDS; TRISUBSTITUTED ALKENES; RHODIUM; CYCLIZATION; YNAMIDES; SYSTEM;
D O I：
10.1021/jacs.6b08818
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium(II)-catalyzed regioselective syn-hydroarylation reaction of homopropargyl amines has been developed, wherein-selectivity is controlled by a cleavable bidentate directing group: Under the optimized reaction conditions, both dialkyl and alkylaryl substrates were found to undergo hydroarylation with high selectivity. The products of this reaction contain a 4,4-disubstituted homoallylic amine motif that is commonly seen in drug molecules and other bioactive compounds.
引用
收藏
页码：13076 / 13081
页数：6
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