P-Chiral Monophosphorus Ligands for Asymmetric Copper-Catalyzed Allylic Alkylation

被引：15
|
作者：
Xiong, Wenrui [1 ]
Xu, Guangqing [2 ]
Yu, Xinhong [1 ]
Tang, Wenjun [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, 130 Meilong Rd, Shanghai 200037, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
ORGANOMETALLICS | 2019年 / 38卷 / 20期
关键词：
SUBSTITUTION-REACTION; ENANTIOSELECTIVE ALLYLATION; CONJUGATE ADDITION; CLOSING METATHESIS; GRIGNARD-REAGENTS; HYDROXYALKYL NHC; EFFICIENT; PHOSPHATES; S(N)2'; CHLORIDES;
D O I：
10.1021/acs.organomet.9b00194
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Asymmetric copper-catalyzed allylic alkylation between allylic bromides and alkyl Grignard reagents using a P-chiral monophosphorus ligand is described. A range of terminal olefins bearing tertiary or quaternary carbon centers were formed in good branched/linear selectivities and excellent enantioselectivities at copper loadings as low as 0.5 mol %.
引用
收藏
页码：4003 / 4013
页数：11
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