P-Chiral Monophosphorus Ligands for Asymmetric Copper-Catalyzed Allylic Alkylation

被引：15

作者：

Xiong, Wenrui ^{[1
]}

Xu, Guangqing ^{[2
]}

Yu, Xinhong ^{[1
]}

Tang, Wenjun ^{[1
,2
]}

机构：

[1] East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, 130 Meilong Rd, Shanghai 200037, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

来源：

ORGANOMETALLICS | 2019年 / 38卷 / 20期

关键词：

SUBSTITUTION-REACTION; ENANTIOSELECTIVE ALLYLATION; CONJUGATE ADDITION; CLOSING METATHESIS; GRIGNARD-REAGENTS; HYDROXYALKYL NHC; EFFICIENT; PHOSPHATES; S(N)2'; CHLORIDES;

D O I：

10.1021/acs.organomet.9b00194

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric copper-catalyzed allylic alkylation between allylic bromides and alkyl Grignard reagents using a P-chiral monophosphorus ligand is described. A range of terminal olefins bearing tertiary or quaternary carbon centers were formed in good branched/linear selectivities and excellent enantioselectivities at copper loadings as low as 0.5 mol %.

引用

页码：4003 / 4013

页数：11

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