Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors (vol 19, pg 4920, 2009)

被引：0

作者：

Truong, Anh P. ^{[1
]}

Aubele, Danielle L. ^{[1
]}

Probst, Gary D. ^{[1
]}

Neitzel, Martin L. ^{[1
]}

Semko, Chris M. ^{[1
]}

Bowers, Simeon ^{[1
]}

Dressen, Darren ^{[1
]}

Hom, Roy K. ^{[1
]}

Konradi, Andrei W. ^{[1
]}

Sham, Hing L. ^{[1
,2
]}

Garofalo, Albert W. ^{[1
]}

Keim, Pamela S. ^{[2
]}

Wu, Jing ^{[2
]}

Dappen, Michael S. ^{[2
]}

Wong, Karina ^{[3
]}

Goldbach, Erich ^{[3
]}

Quinn, Kevin P. ^{[3
]}

Sauer, John-Michael ^{[3
]}

Brigham, Elizabeth F. ^{[4
]}

Wallace, William ^{[5
]}

Nguyen, Lan ^{[5
]}

Hemphill, Susanna S. ^{[5
]}

Bova, Michael P. ^{[5
]}

Bard, Frederique ^{[5
]}

Yednock, Ted A. ^{[1
,2
,3
,4
,5
]}

Basi, Guriqbal ^{[5
]}

机构：

[1] Elan Pharmaceut, Dept Med Chem, San Francisco, CA 94080 USA

[2] Elan Pharmaceut, Dept Proc & Analyt Chem, San Francisco, CA 94080 USA

[3] Elan Pharmaceut, Dept Lead Finding Drug Disposit & Safety Evaluat, San Francisco, CA 94080 USA

[4] Elan Pharmaceut, Dept In Vivo Pharmacol, San Francisco, CA 94080 USA

[5] Elan Pharmaceut, Dept Biol, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2010.10.090

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：7553 / 7553

页数：1

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