Auto-tandem catalysis: facile synthesis of substituted alkylidenecyclohexanones by domino (4+2) cycloaddition-elimination reaction

被引：12
|
作者：
Takasu, Kiyosei [1 ]
Tanaka, Toru [1 ]
Azuma, Takumi [1 ]
Takemoto, Yoshiji [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068571, Japan
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 43期
关键词：
CASCADE;
D O I：
10.1039/c0cc03336g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A catalytic domino reaction producing substituted 2-alkylidene-cyclohexanone from 3-oxymethyl-2-siloxy-1,3-butadienes, which can be prepared from Baylis-Hillman adducts, and alpha, beta-unsaturated ketones is described. The process involves two mechanistically distinct reactions, (4+2) cycloaddition and elimination. Both of these reactions are catalyzed by Tf2NH.
引用
收藏
页码：8246 / 8248
页数：3
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