Description and quantification of cocaine withdrawal signs in Planaria

被引：31
|
作者：
Raffa, RB
Desai, P
机构：
[1] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19140 USA
[2] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA
[3] Temple Univ, TMARC, PSTP Program, Philadelphia, PA 19140 USA
来源：
BRAIN RESEARCH | 2005年 / 1032卷 / 1-2期
关键词：
cocaine; withdrawal signs; Planaria;
D O I：
10.1016/j.brainres.2004.10.052
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous work provided indirect evidence that planarians undergo abstinence-induced withdrawal from cocaine. The present study's purpose was to determine if planarians display withdrawal signs and, if so, to quantify the behaviors. Planarians were soaked in cocaine then transferred to either the same cocaine concentration or cocaine-free water. Compared to the cocaine/cocaine group, the cocaine/water group displayed a significant number of atypical behaviors, providing direct evidence of a 'withdrawal phenomenon' in planarians. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：200 / 202
页数：3
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