[18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106-Selective radioligands for imaging TSPO 18 kDa with PET: Automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls

被引：57
|
作者：
Kuhnast, Bertrand [1 ]
Damont, Annelaure [1 ]
Hinnen, Francoise [1 ]
Catarina, Tony [1 ]
Demphel, Stephane [1 ]
Le Helleix, Stephane [1 ]
Coulon, Christine [1 ]
Goutal, Sebastien [1 ]
Gervais, Philippe [1 ]
Dolle, Frederic [1 ]
机构：
[1] CEA, Serv Hosp Frederic Joliot, I2BM, F-91401 Orsay, France
来源：
APPLIED RADIATION AND ISOTOPES | 2012年 / 70卷 / 03期
关键词：
Fluorine-18; TRACERlab FX-FN; TSPO; 18; kDa; F-18]DPA-714; F-18]FEDAA1106; F-18]PBR111; PERIPHERAL BENZODIAZEPINE-RECEPTOR; SELECTIVE RADIOLIGAND; LIGAND; PBR;
D O I：
10.1016/j.apradiso.2011.10.015
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amounts of such a radiotracer in compliance with GMP standards for application in humans. We present in this technical note automated productions of [F-18]DPA-714, [F-18]PBR111 and [F-18]FEDAA1106, three promising radiotracers for Tspo 18 kDa imaging, using a TRACERlab FX-FN synthesizer. This note also includes the quality control data of the validation batches for the manufacturing qualification of clinical production of [F-18]DPA-714. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：489 / 497
页数：9
相关论文
共 50 条
  • [11] [18F]PBR146 and [18F]DPA-714 in vivo Imaging of Neuroinflammation in Chronic Hepatic Encephalopathy Rats
    Kong, Xiang
    Luo, Song
    Wang, Yun Fei
    Yang, Gui Fen
    Lu, Guang Ming
    Zhang, Long Jiang
    FRONTIERS IN NEUROSCIENCE, 2021, 15
  • [12] Preclinical evaluation of TSPO ligand [18F]DPA-714 for PET imaging of glioma
    Tang, Dewei
    McKinley, Eliot
    Hight, Matthew
    Fu, Allie
    Buck, Jason
    Smith, R.
    Nickels, Mike
    Ansari, Mohammed
    Tantawy, Mohammed
    Manning, H. Charles
    JOURNAL OF NUCLEAR MEDICINE, 2011, 52
  • [13] Automated Radiosynthesis of [18F]ML-10, a PET Radiotracer Dedicated to Apoptosis Imaging, on a TRACERLab FX-FN Module
    Franck Sobrio
    Marie Médoc
    Ludovic Martial
    Jérôme Delamare
    Louisa Barré
    Molecular Imaging and Biology, 2013, 15 : 12 - 18
  • [14] Automated Radiosynthesis of [18F]ML-10, a PET Radiotracer Dedicated to Apoptosis Imaging, on a TRACERLab FX-FN Module
    Sobrio, Franck
    Medoc, Marie
    Martial, Ludovic
    Delamare, Jerome
    Barre, Louisa
    MOLECULAR IMAGING AND BIOLOGY, 2013, 15 (01) : 12 - 18
  • [15] Automated radiosynthesis of [18F]DPA-714 on a commercially available IBA Synthera®
    Vavere, Amy L.
    Ghosh, Arijit
    Diaz, Victor Amador
    Clay, Allison J.
    Hall, Peter M.
    Neumann, Kiel D.
    APPLIED RADIATION AND ISOTOPES, 2024, 207
  • [16] Evaluation of the TSPO (18KDa)/PBR radioligand [18F]DPA-714 in a rat model of focal cerebral ischemia
    Martin, Abraham
    Boisgard, Raphael
    Dolle, Frederic
    Van Camp, Nadja
    Theze, Benoit
    Kassiou, Michael
    Tavitian, Bertrand
    JOURNAL OF NUCLEAR MEDICINE, 2009, 50
  • [17] [18F]THK-523, [18F]T808 and [18F]T807: Radiosynthesis on a TRACERLab FX N Pro synthesizer
    Bramoulle, Yann
    Van-Camp, Nadja
    Cambon, Karine
    Bemelmans, Alexis-Pierre
    Hantraye, Philippe
    Dolle, Frederic
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2015, 58 : S178 - S178
  • [18] In vitro metabolism of [18F]PBR102 and [18F]PBR111 in rats and humans
    Peyronneau, M.
    Loc'h, C.
    Mattner, F.
    Pham, T.
    Jiang, C.
    Pelegrini, P.
    Greguric, I.
    Gregoire, M.
    Katsifis, A.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2011, 38 : S231 - S231
  • [19] EVALUATION OF THE TSPO (18KDA)/PBR RADIOLIGAND [18F] DPA-714 IN A RAT MODEL OF FOCAL CEREBRAL ISCHEMIA
    Martin, A.
    Boisgard, R.
    Dolle, F.
    Theze, B.
    Van Camp, N.
    Kassiou, M.
    Tavitian, B.
    GLIA, 2009, 57 (13) : S54 - S54
  • [20] Electrophilic fluorination and preclinical evaluation of a novel [18F]DPA-714 analogue, [18F]F-DPA
    Keller, Thomas
    Krzyczmonik, Anna M.
    Forsback, Sarita
    Kirjavainen, Anna
    Lopez-Picon, Francisco
    Cacheux, Fanny
    Damont, Annelaure
    Dolle, Frederic
    Haaparanta-Solin, Merja
    Solin, Olof
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2015, 58 : S153 - S153
12345