Deprotection of pinacolyl boronate esters via hydrolysis of intermediate potassium trifluoroborates

被引：127
|
作者：
Yuen, AKL
Hutton, CA [1 ]
机构：
[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
[2] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia
[3] Univ Melbourne, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic 3010, Australia
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 46期
关键词：
D O I：
10.1016/j.tetlet.2005.09.101
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient two-step procedure for the deprotection of pinacolyl organoboronate esters is described. Reaction with excess potassium hydrogen fluoride produces the corresponding stable, crystalline potassium organotrifluoroborate salts. Treatment of the trifluoroborates with either inorganic base or trimethylsilyl chloride and water affords the corresponding organoboronic acid in high yield. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7899 / 7903
页数：5
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