Inhibition of CD147 gene expression via RNA interference reduces tumor cell proliferation, activation, adhesion, and migration activity in the human Jurkat T-lymphoma cell line

被引：28

作者：

Chen, Xiang ^{[1
]}

Su, Juan ^{[1
]}

Chang, Jing ^{[1
]}

Kanekura, Takuro ^{[2
]}

Li, Ji ^{[1
]}

Kuang, Ye Hong ^{[1
]}

Peng, Sheng ^{[1
]}

Yang, Fang ^{[1
]}

Lu, Hui ^{[1
]}

Zhang, Jiang Lin ^{[1
]}

机构：

[1] Cent S Univ, Xiang Ya Hosp, Dept Dermatol, Changsha 410008, Hunan, Peoples R China

[2] Kagoshima Univ, Grad Sch Med & Dent Sci, Field Sensory Organol, Dept Dermatol, Kagoshima 890, Japan

来源：

CANCER INVESTIGATION | 2008年 / 26卷 / 07期

基金：

中国国家自然科学基金;

关键词：

CD147; siRNA; Jurkat; proliferation; activation; lymphoma;

D O I：

10.1080/07357900701867892

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD147, a leukocyte surface molecule over-expressed in T-lymphoma cells, is reportedly associated with lymphocyte activation and proteinase production via interactions with fibroblasts and plays a role in stromal invasion by lymphoma cells. To determine the role of CD147 in the progression of T-lymphoma, we performed siRNA interference-mediated knockdown of CD147 in a CD147-expressing Jurkat T-cell line. CD147 knockdown resulted in the decreased proliferation and migration of Jurkat cells and reduced the adhesion of Jurkat cells to extracelluar matrix fibronectin in vitro. CD147-siRNA inhibited the activation of Jurkat cells via down-regulation of CD25 expression. Our results indicate that CD147 is involved in T-lymphoma progression, a finding useful in efforts to develop targeted therapies to treat patients with T-lymphoma.

引用

页码：689 / 697

页数：9

共 34 条

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