Organocatalytic Enantioselective Decarboxylative Addition of Malonic Acids Half Thioesters to Isatins

被引：101

作者：

Hara, Noriyuki ^{[1
]}

Nakamura, Shuichi ^{[1
]}

Funahashi, Yasuhiro ^{[1
]}

Shibata, Norio ^{[1
]}

机构：

[1] Nagoya Inst Technol, Dept Frontier Mat, Grad Sch Engn, Showa Ku, Nagoya, Aichi 4668555, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 16期

关键词：

aldol reaction; decarboxylative addition; enantioselectivity; organic catalysis; ASYMMETRIC ALDOL CONDENSATION; 1ST TOTAL-SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; SQUARAMIDE DERIVATIVES; (R)-CONVOLUTAMYDINE; SULFONYLIMINES; ACETALDEHYDE; ALKALOIDS; KETONES;

D O I：

10.1002/adsc.201100410

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The organocatalytic enantioselective decarboxylative addition of malonic acids half thioesters to isatins using a squaramide catalyst afforded the products with high enantioselectivity. These products are key intermediates in the synthesis of 3-substituted 3-hydroxy-2-oxindole derivatives. The first enantioselective synthesis of (-)-flustraminol B has been accomplished.

引用

页码：2976 / 2980

页数：5

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