Age-related changes on glucose transport and utilization of human erythrocytes:: Effect of oxidative stress

被引：7

作者：

Güven, M ^{[1
]}

Özkiliç, A ^{[1
]}

Kanigür-Sultuybek, G ^{[1
]}

Ulutin, T ^{[1
]}

机构：

[1] Univ Istanbul, Cerrahpasa Med Fac, Dept Med Biol, Istanbul, Turkey

来源：

GERONTOLOGY | 1999年 / 45卷 / 02期

关键词：

aging; glucose transport and utilization; oxidative stress; erythrocyte;

D O I：

10.1159/000022067

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background: Normal aging is associated with an impairment in glucose homeostasis, Methods: In order to investigate the effect of aging on glucose transport and utilization in erythrocytes, the transport and utilization of glucose were measured in erythrocytes from 10 young (mean age 26 +/- 3 years) and 10 elderly (mean age 70 +/- 7 years) healthy individuals. In addition, the glucose transport and utilization were also measured in the presence of cumene hydroperoxide (CumOOH), a toxic organic hydroperoxide that is known to induce oxidative stress. Results: The levels of glucose transport and utilization were significantly lower in the elderly group than the young group (p < 0.05). The glucose transport and utilization were not altered by CumOOH treatment in either young or elderly individuals. Conclusion: These results indicate an age-related decrease in the both glucose transport and utilization in erythrocytes.

引用

页码：79 / 82

页数：4

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