From novel discovery tools and biomarkers to precision medicine-basic cardiovascular science highlights of 2021/22

被引：6

作者：

Evans, Paul C. ^{[1
,2
]}

Davidson, Sean M. ^{[3
]}

Wojta, Johann ^{[4
,5
]}

Baeck, Magnus ^{[6
,7
,8
]}

Bollini, Sveva ^{[9
]}

Brittan, Mairi ^{[10
]}

Catapano, Alberico L. ^{[11
,12
]}

Chaudhry, Bill ^{[13
]}

Cluitmans, Matthijs ^{[14
,15
]}

Gnecchi, Massimiliano ^{[16
,17
,18
]}

Guzik, Tomasz J. ^{[19
,20
]}

Hoefer, Imo ^{[21
]}

Madonna, Rosalinda ^{[22
,23
]}

Monteiro, Joao P. ^{[10
]}

Morawietz, Henning ^{[24
,25
]}

Osto, Elena ^{[26
,27
]}

Padro, Teresa ^{[28
,29
]}

Sluimer, Judith C. ^{[14
,30
]}

Tocchetti, Carlo Gabriele ^{[31
]}

Van der Heiden, Kim ^{[32
]}

Vilahur, Gemma ^{[28
,29
]}

Waltenberger, Johannes ^{[33
,34
]}

Weber, Christian ^{[35
,36
,37
]}

机构：

[1] Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield S10 2RX, S Yorkshire, England

[2] Univ Sheffield, Insigneo Inst, Sheffield S10 2RX, S Yorkshire, England

[3] UCL, Hatter Cardiovasc Inst, 67 Chenies Mews, London WC1 6HX, England

[4] Med Univ Vienna, Dept Internal Med 2, A-1090 Vienna, Austria

[5] Ludwig Boltzmann Inst Cardiovasc Res, A-1090 Vienna, Austria

[6] Karolinska Inst, Translat Cardiol, S-17177 Stockholm, Sweden

[7] Karolinska Univ Hosp, S-17177 Stockholm, Sweden

[8] Univ Lorraine, U1116 Nancy Univ Hosp, INSERM U1116, Nancy, France

[9] Univ Genoa, Dept Expt Med DIMES, Lgo R Benzi 10, I-16132 Genoa, Italy

[10] Univ Edinburgh, BHF Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

[11] Univ Milan, I-20149 Milan, Italy

[12] Multimed IRCCS, I-20149 Milan, Italy

[13] Newcastle Univ, Biosci Inst, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[14] Maastricht Univ, Cardiovasc Res Inst Maastricht, NL-6200 MD Maastricht, Netherlands

[15] Philips Res, NL-5656 AE Eindhoven, Netherlands

[16] Univ Pavia, Dept Mol Med, Unit Cardiol, I-27100 Pavia, Italy

[17] Fdn IRCCS Policlin San Matteo, Div Cardiol, Unit Translat Cardiol, I-27100 Pavia, Italy

[18] Univ Cape Town, Dept Med, ZA-7700 Cape Town, South Africa

[19] Jagiellonian Univ Med Coll, Dept Internal Med, PL-31008 Krakow, Poland

[20] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland

[21] UMC Utrecht, Cent Diagnost Lab, NL-3584 CX Utrecht, Netherlands

[22] Univ Pisa, Inst Cardiol, Dept Surg Med Mol & Crit Care Area, I-56124 Pisa, Italy

[23] Univ Texas Houston, Dept Internal Med, Cardiol Div, Med Sch, Houston, TX 77065 USA

[24] Tech Univ Dresden, Fac Med, Dept Med 3, Div Vasc Endothelium & Microcirculat, D-01069 Dresden, Germany

[25] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, D-01069 Dresden, Germany

[26] Univ Hosp, Heart Ctr, Inst Clin Chem & Dept Cardiol, CH-8091 Zuric, Switzerland

[27] Univ Zurich, CH-8091 Zuric, Switzerland

[28] IIB St Pau, IR Hosp Santa Creu & St Pau, Cardiovasc Program ICCC, Barcelona 08041, Spain

[29] Inst Carlos III, CiberCV, Madrid 28029, Spain

[30] Univ Edinburgh, Univ BHF Ctr Cardiovasc Sci, Edinburgh EH16 4TJ, Midlothian, Scotland

[31] Univ Naples Federico II, Interdept Hypertens Res Ctr CIRIAPA,Dept Translat, Interdept Ctr Clin & Translat Sci CIRCET, Ctr Basic & Clin Immunol CISI,Cardiooncol Unit, I-80131 Naples, Italy

[32] Erasmus MC, Thoraxctr, Biomed Engn, NL-3015 GD Rotterdam, Netherlands

[33] Univ Munster, Med Fac, Cardiovasc Med, D-48149 Munster, Germany

[34] Diagnost & Therapeut Heart Ctr, CH-8002 Zurich, Switzerland

[35] Ludwig Maximillian Univ LMU Munchen, German Ctr Cardiovasc Res DZHK, Inst Cardiovasc Prevent IPEK, Partner Site Munich Heart Alliance, D-80539 Munich, Germany

[36] Munich Cluster Syst Neurol SyNergy, D-80539 Munich, Germany

[37] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Dept Biochem, NL-6200 MD Maastricht, Netherlands

来源：

CARDIOVASCULAR RESEARCH | 2022年 / 118卷 / 13期

关键词：

Cardiology; Vascular; Biomarkers; Precision medicine; ESC WORKING GROUP; EXTRACELLULAR VESICLES; CLONAL HEMATOPOIESIS; ATHEROSCLEROSIS; INFLAMMATION; COVID-19; ASSOCIATION; CELLS; PAPER; CARDIOTOXICITY;

D O I：

10.1093/cvr/cvac114

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Here, we review the highlights of cardiovascular basic science published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell 'omics are providing new insights into cardiovascular development, inflammation, and disease. We also review recent discoveries on the biology of extracellular vesicles in driving either protective or pathogenic responses. The Nobel Prize in Physiology or Medicine 2021 recognized the importance of the molecular basis of mechanosensing and here we review breakthroughs in cardiovascular sensing of mechanical force. We also summarize discoveries in the field of atherosclerosis including the role of clonal haematopoiesis of indeterminate potential, and new mechanisms of crosstalk between hyperglycaemia, lipid mediators, and inflammation. The past 12 months also witnessed major advances in the field of cardiac arrhythmia including new mechanisms of fibrillation. We also focus on inducible pluripotent stem cell technology which has demonstrated disease causality for several genetic polymorphisms in long-QT syndrome and aortic valve disease, paving the way for personalized medicine approaches. Finally, the cardiovascular community has continued to better understand COVID-19 with significant advancement in our knowledge of cardiovascular tropism, molecular markers, the mechanism of vaccine-induced thrombotic complications and new anti-viral therapies that protect the cardiovascular system.

引用

页码：2754 / 2767

页数：14