A New Iridoid Glycoside from Wine-Processed Corni fructus

被引：1

作者：

Feng, Qingmei ^{[1
,2
,3
]}

Zhang, Hong ^{[4
]}

Wang, Jing ^{[1
,2
,3
]}

Li, Hongbin ^{[1
,2
,3
]}

Zhang, Lingxia ^{[1
,2
,3
]}

Xu, Erping ^{[1
,2
,3
]}

Chen, Suiqing ^{[1
,2
,3
]}

Wang, Zhimin ^{[1
,2
,3
,5
]}

Dai, Liping ^{[1
,2
,3
]}

机构：

[1] Henan Univ Tradit Chinese Med, Zhengzhou 450046, Henan, Peoples R China

[2] Engn Technol Res Ctr Comprehens Dev & Utilizat Au, Zhengzhou 450046, Henan, Peoples R China

[3] Zhengzhou Engn Res Ctr Food Med Homologous Subst, Zhengzhou 450046, Henan, Peoples R China

[4] Zhengzhou Univ, Affiliated Hosp 2, Zhengzhou 450046, Henan, Peoples R China

[5] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2022年 / 16卷 / 05期

关键词：

Iridoid glycoside; wine-processed Corni fructus; anti-inflammatory activity; FRUITS;

D O I：

10.25135/rnp.300.21.10.2232

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new iridoid glycoside, cornusglucoside I (1), and a new natural product methyl 4-(3 ' ,4 ' dihydroxyphenyl)-4-oxobutanoate (2), together with two known isolated compounds (3-4) were obtained from the 30% ethanol extract of the wine-processed Corni fructus. Their structures were clarified by spectroscopic analysis and literature data. The absolute configuration of 1 was elucidated by ECD calculation. By evaluating the NO production induced by LPS in RAW 264.7 cells to assess the anti-inflammatory activities of isolated compounds. Among the tested compounds, compounds 3 and 4 exhibited stronger anti-inflammatory activity than the positive drug dexamethasone (6 mu M), which may be potential anti-inflammatory drugs.

引用

页码：409 / 416

页数：8

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