A New Iridoid Glycoside from Wine-Processed Corni fructus

被引：1
|
作者：
Feng, Qingmei [1 ,2 ,3 ]
Zhang, Hong [4 ]
Wang, Jing [1 ,2 ,3 ]
Li, Hongbin [1 ,2 ,3 ]
Zhang, Lingxia [1 ,2 ,3 ]
Xu, Erping [1 ,2 ,3 ]
Chen, Suiqing [1 ,2 ,3 ]
Wang, Zhimin [1 ,2 ,3 ,5 ]
Dai, Liping [1 ,2 ,3 ]
机构：
[1] Henan Univ Tradit Chinese Med, Zhengzhou 450046, Henan, Peoples R China
[2] Engn Technol Res Ctr Comprehens Dev & Utilizat Au, Zhengzhou 450046, Henan, Peoples R China
[3] Zhengzhou Engn Res Ctr Food Med Homologous Subst, Zhengzhou 450046, Henan, Peoples R China
[4] Zhengzhou Univ, Affiliated Hosp 2, Zhengzhou 450046, Henan, Peoples R China
[5] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
来源：
RECORDS OF NATURAL PRODUCTS | 2022年 / 16卷 / 05期
关键词：
Iridoid glycoside; wine-processed Corni fructus; anti-inflammatory activity; FRUITS;
D O I：
10.25135/rnp.300.21.10.2232
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new iridoid glycoside, cornusglucoside I (1), and a new natural product methyl 4-(3 ' ,4 ' dihydroxyphenyl)-4-oxobutanoate (2), together with two known isolated compounds (3-4) were obtained from the 30% ethanol extract of the wine-processed Corni fructus. Their structures were clarified by spectroscopic analysis and literature data. The absolute configuration of 1 was elucidated by ECD calculation. By evaluating the NO production induced by LPS in RAW 264.7 cells to assess the anti-inflammatory activities of isolated compounds. Among the tested compounds, compounds 3 and 4 exhibited stronger anti-inflammatory activity than the positive drug dexamethasone (6 mu M), which may be potential anti-inflammatory drugs.
引用
收藏
页码：409 / 416
页数：8
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