Clinical significance of humoral compensatory reactions in the acute period of ischemic stroke

To determine the clinical significance of humoral nonspecific reactions in the acute period of ischemic hemispheric stroke (IS), some biochemical and biophysical parameters have been studied in 30 patients (mean age 67 +/- 10 years). Platelet monoaminooxidase (MAO) activity, levels of middle-sized molecules (MM), malonic dialdehyde (MDA) and parameters of the functional state of serum albumin (the effective concentration and binding reserve of albumin) have been measured. Severity of neurological deficit and functional recovery of patients with IS was assessed with the NIHSS and the Barthel index. The control group included 17 age- and sex-matched healthy people (p<0,1). The significant changes in all biochemical and biophysical parameters were seen in patients compared to the control group (p<0,01). The increase in MAO activity in patients was associated with the enhancement of free-radical reactions MDA/MAO: r(s)=+0,62, p=0,0001. The elevation of acceptor capacity of albumin related to the enhancement of its detoxicating function was found in patients with the regression of neurological deficit. It has been assumed that some nonspecific humoral reactions play a pathogenetic role in the acute period of ischemic stroke.