Pulmonary delivery of liposomes co-loaded with SN38 prodrug and curcumin for the treatment of lung cancer

被引：17
|
作者：
Gao, Chengzhi [1 ]
Zhang, Lanfang [2 ]
Xu, Minhao [1 ]
Luo, Yi [1 ]
Wang, Ben [1 ]
Kuang, Meiyan [1 ]
Liu, Xingyou [1 ]
Sun, Meng [1 ]
Guo, Yue [1 ]
Teng, Lesheng [3 ]
Wang, Chenhui [2 ]
Zhang, Yan [2 ]
Xie, Jing [1 ]
机构：
[1] Chongqing Univ Technol, Sch Pharm & Bioengn, 69 Hongguang Rd, Chongqing 400054, Peoples R China
[2] Chongqing Univ, Innovat Drug Res Ctr, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 South Daxuecheng Rd, Chongqing 401331, Peoples R China
[3] Jilin Univ, Sch Life Sci, 2699 Qianjin Rd, Changchun 130012, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2022年 / 179卷
关键词：
Pulmonary delivery; SN38; Curcumin; Lung cancer; MICROFLUIDIC SYNTHESIS; NANOPARTICLES; DOXORUBICIN; ACID;
D O I：
10.1016/j.ejpb.2022.08.021
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A co-delivery system of SN38 (7-ethyl-10-hydroxyl camptothecin) prodrug and CUR (curcumin) was designed for the treatment of lung cancer by pulmonary delivery. SN38 was linked to cell-penetrating peptide (CPP) TAT via a polyethylene glycol (PEG) linker to form the SN38 prodrug (TAT-PEG-SN38). Liposomes co-loaded with amphiphilic TAT-PEG-SN38 and curcumin (Lip-TAT-PEG-SN38/CUR) were successfully prepared by a micro -fluidic method for the treatment of lung cancer via pulmonary delivery. Lip-TAT-PEG-SN38/CUR showed nanometer-sized sphericity and a particle size of 171.21 nm. Besides, Lip-TAT-PEG-SN38/CUR exhibited enhanced antiproliferative effect, increased cell apoptosis induction and improved cell cycle arrest compared to the single agents in vitro. The combination induced significant tumor inhibition in a BALB/c mouse lung cancer model. These results indicated that our SN38 prodrug and curcumin co-delivery system was a promising candidate for lung cancer treatment.
引用
收藏
页码：156 / 165
页数：10
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