Synthesis and anticonvulsant activity of clubbed thiazolidinone-barbituric acid and thiazolidinone-triazole derivatives

被引：63

作者：

Shiradkar, Mahendra R. ^{[1
]}

Ghodake, Mangesh ^{[2
]}

Bothara, Kailash G. ^{[2
]}

Bhandari, Shashikant V. ^{[2
]}

Nikalje, Ana ^{[3
]}

Akula, Kalyan Chakravarthy ^{[1
]}

Desai, Nisheeth C. ^{[4
]}

Burange, Prashant J. ^{[2
]}

机构：

[1] Dr Reddys Labs, 7-1-27, Ameerpet, Hyderabad 500016, Andhra Pradesh, India

[2] AISSMS Coll Pharm, Pune 411001, Maharashtra, India

[3] YB Chavhan Coll Pharm, Aurangabad 431001, Maharashtra, India

[4] Bhavnagar Univ, Dept Chem, Med Chem Lab, Bhavnagar 364001, Gujarat, India

来源：

ARKIVOC | 2007年

关键词：

1,2,4-triazoles; pentylenetetrazole; maximal electroshock; anticonvulsant; neurotoxicity;

D O I：

10.3998/ark.5550190.0008.e08

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of clubbed thiazolidinone-barbituric acid and thiazolidinone-triazole derivatives was synthesized to study the effect of a hydrophobic unit, hydrogen bonding domain and electron-donor group on the compounds' anticonvulsant activity. The structures of the synthesized compounds were confirmed by their spectroscopic data and elemental analysis. All compounds were evaluated for their anticonvulsant activity in two animal models of seizures, viz. maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). The compounds were also evaluated for neurotoxicity. Compounds 4g, 4i, 5g and 5i exhibited excellent anticonvulsant activity in both animal models of seizure.

引用

页码：58 / 74

页数：17

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