A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes

被引：10
|
作者：
Bisaha, SN
Malley, MF
Pudzianowski, A
Monshizadegan, H
Wang, P
Madsen, CS
Gougoutas, JZ
Stein, PD
机构：
[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Discovery Chem, Princeton, NJ 08543 USA
[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Solid State Struct, Princeton, NJ 08543 USA
[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Comp Aided Drug Design, Princeton, NJ 08543 USA
[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Cardiovasc Biol, Princeton, NJ 08543 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 11期
关键词：
mitochondrial ATPase; acylguanidine; chiral synthesis;
D O I：
10.1016/j.bmcl.2005.03.115
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The preferred absolute configuration of two series of F1F0-ATP synthase inhibitors was determined. Although the configuration of the active enantiomer in each series is different, each series presents the same 'triaryl' pharmacophore to the enzyme binding site. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2749 / 2751
页数：3
相关论文
共 50 条
  • [31] Chemical crosslinking of the c subunit of Escherichia coli F1F0-ATPase
    Glavas, N
    Walker, JE
    ACTA PHYSIOLOGICA SCANDINAVICA, 1998, 163 : 335 - 335
  • [32] Reversible ischemic inhibition of F1F0-ATPase in rat and human myocardium
    Ylitalo, K
    Ala-Rämi, A
    Vuorinen, K
    Peuhkurinen, K
    Lepojärvi, M
    Kaukoranta, P
    Kiviluoma, K
    Hassinen, I
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2001, 1504 (2-3): : 329 - 339
  • [33] The dimerization domain of the b subunit of the Escherichia coli F1F0-ATPase
    Revington, M
    McLachlin, DT
    Shaw, GS
    Dunn, SD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (43) : 31094 - 31101
  • [34] MUTANTS IN SUBUNIT-A OF THE ESCHERICHIA-COLI F1F0-ATPASE
    PAULE, CR
    FILLINGAME, RH
    BIOPHYSICAL JOURNAL, 1990, 57 (02) : A352 - A352
  • [35] Dimerization interactions of the b subunit of the Escherichia coli F1F0-ATPase
    McLachlin, DT
    Dunn, SD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (34) : 21233 - 21239
  • [36] MOLECULAR-BIOLOGY OF THE F1F0-ATPASE OF ESCHERICHIA-COLI
    GIBSON, F
    PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 1984, 16 : S47 - S47
  • [37] F1F0-ATPASE AS AN AUTOANTIGENIC TARGET IN PATIENTS WITH ANTI-MITOCHONDRIAL ANTIBODY NEGATIVE PRIMARY BILIARY CIRRHOSIS
    Mytilinaiou, Maria G.
    Komorowski, Lars
    Rigopoulou, Eirini I.
    Janssen, Anthonina
    Probst, Christian
    Vergani, Diego
    Bogdanos, Dimitrios P.
    HEPATOLOGY, 2010, 52 (04) : 493A - 493A
  • [38] DIBUTYLTIN-3-HYDROXYFLAVONE BROMIDE - A FLUORESCENT INHIBITOR OF F1F0-ATPASE
    USTA, J
    GRIFFITHS, DE
    APPLIED ORGANOMETALLIC CHEMISTRY, 1993, 7 (03) : 193 - 200
  • [39] Enzyme level of enterococcal F1F0-ATPase is regulated by pH at the step of assembly
    Arikado, E
    Ishihara, H
    Ehara, T
    Shibata, C
    Saito, H
    Kakegawa, T
    Igarashi, K
    Kobayashi, H
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 259 (1-2): : 262 - 268
  • [40] Role of F1F0-ATPase in the growth of Streptococcus mutans GS5.
    Suzuki, T
    Tagami, J
    Hanada, N
    JOURNAL OF DENTAL RESEARCH, 1999, 78 (05) : 1131 - 1131
12345