Copper-catalyzed C-H alkylation of 8-aminoquinolines via 8-amide chelation assistance

被引：31
|
作者：
Xia, Xiao-Feng [1 ]
Zhu, Su-Li [1 ]
Gu, Zhen [1 ]
Wang, Haijun [1 ]
机构：
[1] Jiangnan Univ, Sch Chem & Mat Engn, Minist Educ, Key Lab Food Colloids & Biotechnol, Wuxi 214122, Jiangsu, Peoples R China
来源：
RSC ADVANCES | 2015年 / 5卷 / 37期
基金：
美国国家科学基金会;
关键词：
QUINOLINE N-OXIDES; ALIPHATIC CARBOXYLIC-ACIDS; ALPHA-AMINO-ACIDS; MILD CONDITIONS; ARYL HALIDES; DIRECTING GROUP; C-8; POSITION; ARYLATION; AGENTS; ANTIMALARIALS;
D O I：
10.1039/c4ra16896h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A copper-catalyzed 8-amide chelation- assisted C-H alkylation of 8-aminoquinolines is described. The secondary and tertiary alkyl carboxylic acids can be used as alkylating agents. This reaction allows for the highly regioselective preparation of C2-adamantyl 8-aminoquinoline scaffolds by the decarboxylative alkylation catalytic system.
引用
收藏
页码：28892 / 28895
页数：4
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