The association between cognition and functional outcome in first-episode patients with schizophrenia: mystery resolved?

被引：41
|
作者：
van Winkel, R.
Myin-Germeys, I.
De Hert, M.
Delespaul, P.
Peuskens, J.
van Os, J.
机构：
[1] Maastricht Univ, Dept Psychiat & Neuropsychol, European Grad Sch Neurosci, NL-6200 MD Maastricht, Netherlands
[2] Inst Psychiat, Inst Med Psychol, London, England
[3] Catholic Univ Louvain, Univ Psychiat Ctr, Kortenberg, Belgium
来源：
ACTA PSYCHIATRICA SCANDINAVICA | 2007年 / 116卷 / 02期
关键词：
intelligence; schizophrenia; outcomes research;
D O I：
10.1111/j.1600-0447.2007.01014.x
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objective: The presence of a prospective association between cognition and functional outcome in first episode patients with schizophrenia is much debated. Method: Associations between Intelligence Quotient (IQ) measures and functional outcome were assessed at the first hospitalization and after 10 years follow-up. Results: Functional outcome was associated with estimated premorbid IQ and IQ at 10-year follow-up, but not with IQ assessed at first hospitalization. Conclusion: The presence of a prospective as well as a cross-sectional relationship of the global cognitive measure IQ with 10-year functional outcome could be established. However, assessing associations between cognitive measures assessed at first hospitalization and subsequent functional outcome, can give inconclusive results due to non-uniform intellectual deterioration from premorbid level in the period preceding the first hospitalization.
引用
收藏
页码：119 / 124
页数：6
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