A new one-pot arylacetylene synthesis:: 4-RC6H4CC(TMS) from 4-RC6H4CN and LiC(TMS)3(THF)2 via Li[N(TMS)C(C6H4R-4)C(TMS)2](THF) (TMS = SiMe3, R = H, F, Br, OMe or But)

被引：11
|
作者：
Lappert, MF [1 ]
Layh, M [1 ]
机构：
[1] Univ Sussex, Chem Lab, Brighton BN1 9QJ, E Sussex, England
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 26期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1016/S0040-4039(98)00933-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of LiC(TMS)(3)(THF)(2) with the nitrile 4-RC6H4CN in Et2O at ambient temperature yields the new lithium I-aza-allyl Li[N(TMS)C(C6H4R-4)C(TMS)(2)](THF) which readily eliminates LiN(TMS)(2) upon heating in refluxing benzene yielding the acetylene 4-RC6H4C=C(TMS) in quantitative (TMS = SiMe3; R = H, Br, OMe or Bu-t) or low (R = F) yield. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：4745 / 4748
页数：4
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