Synthesis of neomycin-DNA/peptide nucleic acid conjugates

被引：26

作者：

Charles, I ^{[1
]}

Arya, DP ^{[1
]}

机构：

[1] Clemson Univ, Dept Chem, Med Chem Lab, Clemson, SC 29634 USA

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2005年 / 24卷 / 02期

关键词：

neomycin; PNA; DNA; neomycin isothiocyanate;

D O I：

10.1081/CAR-200059973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syntheses of neomycin conjugates of DNA and peptide nucleic acid (PNA) is reported. The DNA and PNA conjugates were prepared by coupling neomycin isothiocyanate with the amino group of DNA/PNA in order to form a thiourea linkage. The use of neomycin isothiocyanate as an electrophilic reagent for a general route to aminoglycoside-coupled nucleic acid biopolymers is described.

引用

页码：145 / 160

页数：16

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