Determination of drug load in porous silicon microparticles by calorimetry

被引：29

作者：

Salonen, J ^{[1
]}

Paski, J ^{[1
]}

Vähä-Heikkilä, K ^{[1
]}

Heikkilä, T ^{[1
]}

Björkqvist, M ^{[1
]}

Lehto, VP ^{[1
]}

机构：

[1] Univ Turku, Dept Phys, Turku 20014, Finland

来源：

PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE | 2005年 / 202卷 / 08期

关键词：

D O I：

10.1002/pssa.200461204

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Different kind of drugs can be loaded into the porous silicon microparticles for oral dosing. In cases where the drug is in its crystalline form in the pores, the amount of the loaded drug can be determined accurately using a calorimetric method, thermoporometry. Even if the drug substance is not in crystalline form a sophisticated estimation can be given. In this work ibuprofen, antipyrine, and ranitidine have been studied. Ibuprofen and antipyrine were easily detected and quantified, but ranitidine, which does not penetrate into the PSi microparticles in its crystalline form, could only be qualitatively determined. The possibility to quantify this kind of drug substance is also discussed. (c) 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1629 / 1633

页数：5

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