Heterodimeric IL-15 regulates the balance of effector and regulatory cells, promoting anti-cancer tumor effects

被引:0
|
作者
Felber, Barbara [1 ]
Bergamaschi, Cristina [1 ]
Ng, Sin Man [1 ]
Chen, Stephanie [1 ]
Bear, Jenifer [1 ]
Alicea, Candido [1 ]
Beach, Rachel Kelly [1 ]
Chertova, Elena [2 ]
Sowder, Raymond [2 ]
Pavlakis, George [1 ]
机构
[1] NCI, Ctr Canc Res, Frederick, MD 21701 USA
[2] Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD USA
来源
JOURNAL OF IMMUNOLOGY | 2015年 / 194卷
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CCR4P.213
引用
收藏
页数:2
相关论文
共 50 条
  • [41] Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive and Immunosuppressive Cells in the Anti-tumor Efficacy
    Mortara, Lorenzo
    Balza, Enrica
    Bruno, Antonino
    Poggi, Alessandro
    Orecchia, Paola
    Carnemolla, Barbara
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [42] Tumor burden reduction in an orthotopic non-muscle-invasive bladder cancer model using IL-15 analogue (ALT-803) targeting T regulatory cells
    Gomes, Evan
    Miyake, Makito
    Zhang, Ge
    Goodison, Steve
    Egan, Jack
    Rhode, Peter
    Wong, Hing C.
    Rosser, Charles Joel
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (06)
  • [43] Combining Deep™ IL-12 Primed and Deep™ IL-15 Primed T cells leverages complementary mechanisms to enhance anti-tumor activity
    Sackton, Katharine
    Geretti, Elena
    Cao, Pengpeng
    Carey, Shawn
    Liang, Xiaoyan
    Nardozzi, Jonathan
    Gui, Zishu
    Worthylake, Alicia
    Leary, Glenn
    Hewes, Becker
    Maniar, Tap
    Fitzgerald, Jonathan
    Rakestraw, Andy
    Sauer, Karsten
    Jones, Douglas
    Andresen, Thomas
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [44] Regulation of Cytokine Release and Anti-Tumor Effects of Expanded NK and CAR NK by ALT-803, an IL-15 Superagonist
    Chu, Yaya
    Hamby, Carl
    Misarti, Jesse
    Tesoriero, Jack
    Rosenblum, Jeremy
    Wong, Hing C.
    Lee, Dean A.
    Cairo, Mitchell S.
    PEDIATRIC BLOOD & CANCER, 2017, 64 : S100 - S101
  • [45] IL-15 ANALOGUE (ALT-803) TARGETING T REGULATORY CELLS CAUSES TUMOR BURDEN REDUCTION IN AN ORTHOTOPIC NON-MUSCLE INVASIVE BLADDER CANCER MODEL
    Gomes, Evan
    Miyake, Makito
    Zhang, Ge
    Goodison, Steven
    Egan, Jack
    Rhode, Peter
    Wong, Hing
    Rosser, Charles
    JOURNAL OF UROLOGY, 2013, 189 (04): : E239 - E239
  • [46] IL-15Rα-IgG1-Fc Enhances IL-2 and IL-15 Anti-tumor Action through NK and CD8+ T Cells Proliferation and Activation
    Wu, Zhongfu
    Xu, Yibing
    JOURNAL OF MOLECULAR CELL BIOLOGY, 2010, 2 (04) : 217 - 222
  • [47] Foxp1 Regulates Anti-tumor Effector Functions of CD8+T cells in Ovarian Cancer
    Stephen, Tom
    Takata, Hiroshi
    Feng, Xiaoming
    Wang, Haikun
    Rutkowski, Melanie
    Allegrezza, Michael
    Hu, Hui
    Conejo-Garcia, Jose
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [48] QL415, a tumor targeted IL-15 fusion protein stimulating both lymphoid and myeloid immune cells for optimal anti-tumor immune response
    Tang, Irene
    Schwimmer, Lauren
    Jin, Monica
    Gu, Shenda
    Prior, Wei Wei
    Capacio, Arianne
    Tran, Hieu V.
    Chan, Allan
    McClain, Anna
    Chen, Shihao
    Cao, Chuanzeng
    Wu, Xiaoran
    Xu, Yanling
    Guan, Dongmei
    Chen, Xi
    Su, Xianli
    CANCER RESEARCH, 2022, 82 (12)
  • [49] The Tt-cell growth factor cocktail IL-2/IL-15/IL-21 enhances expansion and effector function of tumor-infiltrating T cells in a novel process developed by iovance
    Frank, Ian
    Simpson-Abelson, Michelle
    Lotze, Michael
    Ritthipichai, Krit
    Mosychuk, Christopher
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [50] Glypican-3-Specific CAR NKT Cells Armored with IL-15 Mediate Potent Anti-Tumor Response Against Hepatocellular Carcinoma
    Shaik, Rahamthulla
    Rathi, Purva
    Schneller, Netta
    Thao Nguyen
    Guo, Linjie
    Courtney, Amy
    Fleurence, Julien
    Metelitsa, Leonid
    Heczey, Andras
    MOLECULAR THERAPY, 2020, 28 (04) : 34 - 35