Using anxiolytics in epilepsy: neurobiological, neuropharmacological and clinical aspects

被引：14

作者：

Mula, Marco ^{[1
,2
,3
]}

机构：

[1] St Georges Univ Hosp NHS Fdn Trust, Atkinson Morley Reg Neurosci Ctr, Blackshaw Rd, London SW17 0QT, England

[2] South West London & St Georges Mental Hlth Trust, Dept Neuropsychiat, London, England

[3] St Georges Univ London, Inst Med & Biomed Sci, London, England

来源：

EPILEPTIC DISORDERS | 2016年 / 18卷 / 03期

关键词：

epilepsy; anxiety; antiepileptic drugs; benzodiazepines; GABA; GENERALIZED ANXIETY DISORDER; SEROTONIN TRANSPORTER BINDING; PANIC DISORDER; PARADOXICAL REACTION; ANTIEPILEPTIC DRUGS; MOLECULAR TARGETS; GABA(A) RECEPTORS; PREGABALIN; HIPPOCAMPUS; MULTICENTER;

D O I：

10.1684/epd.2016.0837

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Anxiety disorders represent a common psychiatric comorbidity in patients with epilepsy, affecting prognosis and quality of life. However, they are still underdiagnosed and undertreated. In clinical practice, a number of compounds are currently used as anxiolytics, with benzodiazepines being the most popular. Other drug classes, especially antiepileptic drugs, are increasingly prescribed for the treatment of anxiety. This article discusses the neurobiological targets and basic neuropharmacological aspects of anxiolytics in order to give the reader clear insight into their activity and mechanism of action. Clinical data regarding the treatment of anxiety in both adults and children with epilepsy are also summarised, emphasising the need for further studies.

引用

页码：217 / 227

页数：11

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