Preparation of Pyrazinamide Eutectics versus Cocrystals Based on Supramolecular Synthon Variations

被引：27
|
作者：
Rajbongshi, Trishna [1 ]
Sarmah, Kashyap Kumar [1 ]
Sarkar, Ankita [1 ]
Ganduri, Ramesh [2 ]
Cherukuvada, Suryanarayan [2 ]
Thakur, Tejender S. [3 ]
Thakuria, Ranjit [1 ]
机构：
[1] Gauhati Univ, Dept Chem, Gauhati 781014, Assam, India
[2] Indian Inst Sci, Solid State & Struct Chem Unit, Bengaluru 560012, Karnataka, India
[3] CSIR Cent Drug Res Inst, Mol & Struct Biol Div, Lucknow 226031, Uttar Pradesh, India
来源：
CRYSTAL GROWTH & DESIGN | 2018年 / 18卷 / 11期
关键词：
CO-CRYSTAL; PHARMACEUTICAL COCRYSTALS; ACIDS; CAFFEINE; NICOTINAMIDE; DRUG; MIXTURES; DESIGN;
D O I：
10.1021/acs.cgd.8b00878
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cocrystallization of the antituberculosis drug pyrazinamide (PZA) with several substituted aromatic carboxylic acids as coformers was studied. The combinations were analyzed by X-ray diffraction and melting behavior to assess the formation of eutectic versus cocrystal. Benzoic acid, cinnamic acid, and N-heterocycle coformers gave eutectics, whereas the majority of their hydroxyl/methoxy substitutes formed cocrystals with PZA. X-ray crystal structures were obtained for some cocrystals, and binary phase diagrams were constructed to determine eutectic compositions. Differences in functional group position and variations in supramolecular growth were found to dictate the formation of eutectics versus cocrystals. Supramolecular synthon energy calculations on selected combinations validated the formation of eutectic versus cocrystal.
引用
收藏
页码：6640 / 6651
页数：12
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