Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water

被引：37

作者：

Fu, Yajie ^{[1
]}

Lu, Zeping ^{[1
]}

Fang, Ke ^{[1
]}

He, Xinyi ^{[1
]}

Xu, Huajin ^{[1
]}

Hu, Yi ^{[1
]}

机构：

[1] Nanjing Tech Univ, Sch Pharmaceut Sci, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Peoples R China

来源：

RSC ADVANCES | 2020年 / 10卷 / 18期

基金：

中国国家自然科学基金;

关键词：

CATALYZED ELECTROPHILIC SUBSTITUTION; BIOCATALYTIC PROMISCUITY; KNOEVENAGEL CONDENSATION; BOND FORMATION; SOLID ACID; ALDEHYDES; INDOLE; FACILE;

D O I：

10.1039/c9ra10014h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.

引用

页码：10848 / 10853

页数：6

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